To make this delightful Apple Bubble Up Casserole gluten-free without sacrificing its comforting taste and texture, you can easily swap a few ingredients. Replace the regular Pillsbury Grands Jr biscuits with a gluten-free biscuit dough, available in many health food sections or specialty stores. Ensure it's similar in texture to the original to maintain that fluffy, tender consistency we love in this casserole. For the apple pie filling, check the labels to make sure there are no hidden gluten-containing ingredients or make your own using fresh apples, sugar, cinnamon, and a gluten-free thickener like cornstarch. The butterscotch chips and other ingredients are naturally gluten-free, but it's always good practice to double-check for cross-contamination warnings on packaging.