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+ servings
Close-up of cheesy casserole bite showing soft interior and seasoned beef

Cattle Drive Casserole

Prep Time 15 minutes
Cook Time 30 minutes
Total Time 45 minutes
A hearty Cattle Drive Casserole featuring a Bisquick crust, seasoned ground beef, peppers, onions, tomatoes, sour cream, and cheddar cheese baked to golden perfection.
6 Servings

Ingredients

  • 2 ½ cups Bisquick
  • 1 cup water add more if needed for soft dough
  • 1 ½ pounds ground beef
  • 1 can Rotel fire-roasted tomatoes with green chilis
  • 4 ounce green chilis can
  • 1 packet taco seasoning mix
  • 1 red pepper diced
  • 1 onion diced
  • ½ cup sour cream
  • ½ cup mayonnaise
  • 1 teaspoon garlic powder
  • 1 ¾ cups cheddar cheese shredded
  • Salt and pepper to taste

Instructions
 

  1. Preheat the oven: Heat oven to 350°F (175°C). Lightly grease a 9x13-inch baking dish with nonstick spray.
  2. Cook the beef and vegetables: In a skillet over medium-high heat, cook ground beef, onion, and red pepper until the meat is fully browned and vegetables are tender. Stir in taco seasoning, salt, and pepper.
  3. Prepare the sour cream mixture: In a medium bowl, combine sour cream, mayonnaise, garlic powder, and ½ cup of the shredded cheddar cheese. Mix until smooth.
  4. Prepare the crust: In another bowl, mix Bisquick with water until a soft dough forms. Press the dough evenly into the bottom of the prepared baking dish. Bake for 5–7 minutes until lightly golden.
  5. Assemble the casserole: Remove crust from oven. Spread the beef mixture evenly over the crust. Top with diced tomatoes and green chilis. Gently spread the sour cream mixture across the top.
  6. Add cheese and bake: Sprinkle the remaining cheddar cheese over the top. Return dish to the oven and bake for 30 minutes, or until the cheese is melted and bubbly.
  7. Serve: Allow to cool slightly before serving. Slice into squares and enjoy warm.

Notes

To make this casserole gluten-free, substitute the Bisquick with a certified gluten-free baking mix. Confirm that the taco seasoning and canned products (such as tomatoes and chilis) are labeled gluten-free to avoid hidden gluten sources.
If you’d like to switch things up, you can use any standard biscuit mix, just be sure it’s gluten-free if needed. For extra flavor, add a teaspoon of garlic powder to the mix before preparing your dough. You’ll want about 2 to 2½ cups of baking mix to form the crust. A homemade gluten-free baking mix also works beautifully here!
Cornbread mix is another delicious option for the base. If you go this route, use two (7-ounce) packets, prepare according to the package directions (usually with milk and eggs), and pre-bake the crust for about 15 minutes before assembling the casserole as directed above. This adds a slightly sweet, hearty twist that pairs well with the Tex-Mex flavors.

Nutrition

Serving: 1serving | Calories: 843kcal | Carbohydrates: 44g | Protein: 33g | Fat: 59g | Saturated Fat: 21g | Polyunsaturated Fat: 11g | Monounsaturated Fat: 21g | Trans Fat: 1g | Cholesterol: 134mg | Sodium: 1598mg | Potassium: 644mg | Fiber: 4g | Sugar: 12g | Vitamin A: 1713IU | Vitamin C: 38mg | Calcium: 392mg | Iron: 5mg
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